首 页 | 杂志介绍 | 编委会 | 特约专家 | 期刊订阅 | 学术公告 | English
抗Tr抗体阳性副肿瘤性小脑变性1例
作者: 林翔、田淑芬、李恒、贺电
单位:贵州医科大学附属医院神经内科 贵阳 550001
关键词: 副肿瘤性小脑变性、抗体、免疫反应
分类号:R742
出版年·卷·期(页码):2020·46·第 8 期(495-496)
摘要:
神经系统副肿瘤综合征(paraneoplastic neurological syndromes, PNS)是一组与肿瘤相关的疾病,可影响神经系统的任何部分,这些疾病不是由于肿瘤转移和/或局部侵润神经系统引起,而是通常与肿瘤诱导的免疫反应有关[1-2].副肿瘤性小脑变性(paraneoplastic cerebellar degeneration, PCD),是PNS中最常见的一种,PNS相关抗体中抗Tr抗体与PCD密切相关.现将我院2019年收治的1例抗Tr抗体阳性PCD 患者临床资料进行分析,旨在提高对该病的认识.
参考文献:

[1] 任海涛,徐晓璐,关鸿志,范思远,钱敏,杨洵哲,李力波,马明圣,邸卫英,张炜华.自身免疫性小脑炎相关抗神经抗体的筛查与临床意义[J].中华神经科杂志,2019,(4).304-309.10.3760/cma.j.issn.1006-7876.2019.04.009.

[2] 邹飞,孔维敏,刘波.抗Yo抗体阳性的副肿瘤性小脑变性研究进展[J].中国神经精神疾病杂志,2018,(1).58-61.10.3969/j.issn.1002-0152.2018.01.013.

[3] Graus  Francesc,Dalmau  Josep.Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors[J].2019,(9).535-548.

[4] Hiroko Kitanosono,Masakatsu Motomura,Hiroki Tomita,Hiroshi Iwanaga,Naoki Iwanaga,Takashi Irioka,Hirokazu Shiraishi,Akira Tsujino.[Paraneoplastic Cerebellar Degeneration with Lambert-Eaton Myasthenic Syndrome: A Report of an Effectively Treated Case and Systematic Review of Japanese Cases].[J].2019,(2).167-174.10.11477/mf.1416201237.

[5] Alberto Vogrig,Andrea Bernardini,Gian Luigi Gigli,Elisa Corazza,Alessandro Marini,Samantha Segatti,Martina Fabris,Jér?me Honnorat,Mariarosaria Valente.Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature[J].2019,(5).976-982.10.1007/s12311-019-01075-9.

[6] Picard  Geraldine,Karantoni  Evgenia,Psimaras  Dimitri,Antoine  Jean-Christophe,Camdessanche  Jean-Philippe,Delattre  Jean-Yves,Ducray  Francois,Dehais  Caroline,Berzero  Giulia,Rogemond  Veronique,De Seze  Jerome,Honnorat  Jerome,Liou-Schischmanoff  Amelie,Thomas  Laure,Candelier  Gaelle.Early intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with onconeural antibodies[J].2018,(7).789-792.

[7] Psimaras  Dimitri,Berzero  Giulia.Neurological paraneoplastic syndromes: an update[J].2018,(6).359-367.

[8] .Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias[J].2016,(2).213-232.10.1007/s12311-015-0664-x.

[9] Christian  Probst,Lars  Komorowski,Esther  de Graaff,Marleen  van Coevorden-Hameete,Veronique  Rogemond,Jerome  Honnorat,Lidia  Sabeter,Francesc  Graus,Sven  Jarius,Raymond  Voltz,Brigitte  Wildemann,Diego  Franciotta,Inga M  Bl?cker,Wolfgang  Schlumberger,Winfried  St?cker,Peter A E  Sillevis Smitt.Standardized test for anti-Tr/DNER in patients with paraneoplastic cerebellar degeneration.[J].2015,(2).e68.10.1212/NXI.0000000000000068.

[10] Dersch  Rick,Berger  Benjamin,Bischler  Patricia,Stich  Oliver,Hottenrott  Tilman,Rauer  Sebastian."Non-classical" paraneoplastic neurological syndromes associated with well-characterized antineuronal antibodies as compared to "classical" syndromes - More frequent than expected[J].2015,(1).58-61.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
Copyright@2007-2016 中山大学附属第一医院(广州)期刊有限责任公司
地址:广州中山二路58号中山大学附属第一医院门诊楼13楼 邮编:510080 电话:020-87332686 87331494 EMAIL:zgsjjs@126.com
粤ICP备10090623号
本系统由北京博思汇文数字科技有限公司设计开发 技术服务电话:400-921-9838